[Structure-reactivity relationships and delayed neurotoxicity of organophosphorus compounds].
نویسنده
چکیده
A correlation has been found between the reactivity in the alkaline hydrolysis reaction of a new series of organophosphates and their ability or disability to produce the clinical manifestations of delayed neurotoxicity in hen. At a dose of 1000 mg/kg only compounds exceeding a lower limit of reactivity (about 6x10-2 M-1S-1) are active.
منابع مشابه
Organophosphorus ester-induced chronic neurotoxicity.
Organophosphorus compounds are potent neurotoxic chemicals that are widely used in medicine, industry, and agriculture. The neurotoxicity of these chemicals has been documented in accidental human poisoning, epidemiological studies, and animal models. Organophosphorus compounds have 3 distinct neurotoxic actions. The primary action is the irreversible inhibition of acetylcholinesterase, resulti...
متن کاملEster-induced Delayed Neurotoxicity
Most organophosphorus esters are direct inhibitors or are rapidly converted to inhibitors of acetylcholinesterase (AChE, EC 3.1.1.7) (1-3). Some of these compounds produce a more persistent effect: delayed neurotoxicity. In humans, organophosphorus ester-induced delayed neurotoxicity (OPIDN) results in a flaccid paresis which develops distally in the legs and spreads to the hands and thighs. In...
متن کاملOrganophosphorus and other inhibitors of brain 'neurotoxic esterase' and the development of delayed neurotoxicity in hens.
1. The delayed neurotoxic effects of some organophosphorus compounds are associated with phosphorylation of the active site of a nervous-tissue enzyme capable of hydrolysing phenyl phenylacetate. 2. Neurotoxic organophosphorus compounds and some carbamates and sulphonyl fluorides progressively inhibit the enzyme, attaching a substituent covalently at the active site. 3. Prolonged inhibition of ...
متن کامل484-497 Abou-donia Aug03
Organophosphorus compounds are potent neurotoxic chemicals that are widely used in medicine, industry, and agriculture. The neurotoxicity of these chemicals has been documented in accidental human poisoning, epidemiological studies, and animal models. Organophosphorus compounds have 3 distinct neurotoxic actions. The primary action is the irreversible inhibition of acetylcholinesterase, resulti...
متن کاملRelationship of the acylation of membrane esterases and proteins to the teratogenic action of organophosphorus insecticides and eserine in developing hen eggs.
The yolk sac membrane from hen eggs contains esterases that hydrolyze phenyl phenylacetate OpPA) and are sensitive to inhibition, both in vitro and in vivo, by many organophosphorus compounds and by eserine. These esterases are the principal proteins in the membrane which are phosphorylated by 3H-diisopropyl phosphorofluoridate. Inhibition of this mixture of PPA-hydrolyzing esterases in viuo do...
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ورودعنوان ژورنال:
- Zeitschrift fur Naturforschung. Section C, Biosciences
دوره 31 7-8 شماره
صفحات -
تاریخ انتشار 1976